Single-Walled Carbon Nanotubes Inhibit the Cytochrome P450 Enzyme, CYP3A4
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چکیده
منابع مشابه
Single-Walled Carbon Nanotubes Inhibit the Cytochrome P450 Enzyme, CYP3A4.
We report a detailed computational and experimental study of the interaction of single-walled carbon nanotubes (SWCNTs) with the drug-metabolizing cytochrome P450 enzyme, CYP3A4. Dose-dependent inhibition of CYP3A4-mediated conversion of the model compound, testosterone, to its major metabolite, 6β-hydroxy testosterone was noted. Evidence for a direct interaction between SWCNTs and CYP3A4 was a...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep21316